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Salmonella : Yeni superbug

Yüksek düzeyde siprofloksasin direnci gösteren Salmonella enterica Kentucky serotipi izole edildi..

National Salmonella surveillance systems from France, England and Wales, Denmark, and the United States identified the recent emergence of multidrug-resistant isolates of Salmonella enterica serotype Kentucky displaying high-level resistance to ciprofloxacin. A total of 489 human cases were identified during the period from 2002 (3 cases) to 2008 (174 cases). These isolates belonged to a single clone defined by the multilocus sequence type ST198, the XbaI-pulsed-field gel electrophoresis cluster X1, and the presence of the Salmonella genomic island 1 variant SGI1-K. This clone was probably selected in 3 steps in Egypt during the 1990s and the early 2000s and has now spread to several countries in Africa and, more recently, in the Middle East. Poultry has been identified as a potential major vehicle for infection by this clone. Continued surveillance and appropriate control measures should be implemented by national and international authorities to limit the spread of this strain.

International Spread of an Epidemic Population of Salmonella enterica Serotype Kentucky ST198 Resistant to Ciprofloxacin

  1. Simon Le Hello1,
  2. Rene S. Hendriksen2,
  3. Benoît Doublet3,
  4. Ian Fisher4,
  5. Eva Møller Nielsen5,
  6. Jean M. Whichard6,
  7. Brahim Bouchrif7,
  8. Kayode Fashae8,
  9. Sophie A. Granier9,
  10. Nathalie Jourdan-Da Silva10,
  11. Axel Cloeckaert3,
  12. E. John Threlfall4,
  13. Frederick J. Angulo6,
  14. Frank M. Aarestrup2,
  15. John Wain4 and
  16. François-Xavier Weill1

+ Author Affiliations


  1. 1Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Centre National de Référence des Salmonella, World Health Organization (WHO) Collaborating Centre for Reference and Research on Salmonella, Paris, France

  2. 2WHO Collaborating Centre for Antimicrobial Resistance in Food-Borne Pathogens and EU Community Reference Laboratory for Antimicrobial Resistance, National Food Institute, Technical University of Denmark, Copenhagen

  3. 3Institut National de la Recherche Agronomique (INRA), UR1282, Infectiologie Animale et Santé Publique, Nouzilly, France

  4. 4Health Protection Agency, Laboratory for Gastrointestinal Infections, Centre for Infections, London, United Kingdom

  5. 5Department of Microbiological Surveillance and Research, Statens Serum Institute, Copenhagen, Denmark

  6. 6Division of Foodborne, Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

  7. 7Institut Pasteur du Maroc, Casablanca, Morocco

  8. 8Department of Microbiology, University of Ibadan, Nigeria

  9. 9Agence Franc xaise de Sécurité Sanitaire des Aliments, Laboratoire d’études et de recherches sur la qualité des aliments et sur les procédés agro-alimentaires (LERQAP), Unité Caractérisation et Epidémiologie Bactérienne, Maisons-Alfort

  10. 10Département des Maladies Infectieuses, Institut de Veille Sanitaire, Saint-Maurice, France
  1. Correspondence: François-Xavier Weill, MD, PhD, Centre National de Référence des Salmonella, Unité des Bactéries Pathogènes Entériques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, France (fxweill@pasteur.fr).

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